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Long-Term Safety Considerations: While safety data from clinical trials spanning up to 24 weeks is reassuring, long-term safety data spanning years of continuous use remains limited

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Synaptogenesis and Dendritic Spine Formation Independent of the specific HGF-binding biochemistry, Dihexa treatment of cultured rat hippocampal neurons was reported to increase dendritic spine density roughly three-fold over 5 days (approximately 41 spines per 50 um of dendrite with Dihexa versus 15 with vehicle), with newly formed spines containing normal synaptic machinery (VGLUT1, synapsin, PSD-95) and functional AMPA-receptor-mediated activity

Its not only the overload of carbs and fat that drives insulin resistance

Yin et al., 2022

Immunohistochemistry revealed elevated expression levels of MAPL, SUMO1 and cleaved caspase-3 in the degenerated IVD tissues, with the highest levels observed in the IVDD + AAV-MAPL group